A motivated and detail-oriented Bachelor of Pharmacy (B.Pharm) student with a strong foundation in pharmaceuticalsciences, pharmacognosy , and industrial pharmacy. Passionate aboutdrug research, formulation development, andclinical pharmacy. Skilled in laboratory techniques, drug analysis, and pharmaceutical calculations . Eager to applytheoretical knowledge in practical settings and contribute to the healthcare and pharmaceutical industry

Crown Flower (Calotropis gigantea) as a Potential Anti-Diabetic Agent                              Calotropis gigantea, commonly known as crown flower, is a traditional medicinal plant recognized for its wide range of pharmacological properties. Recent studies have highlighted its potential in managing diabetes mellitus, a chronic metabolic disorder characterized by persistent hyperglycaemia and associated complications.

Methods:

The hypoglycemic effect of Calotropis gigantea was evaluated in normal rats using chloroform extracts of its leaves and flowers at doses of 10, 20, and 50 mg/kg, administered orally. To assess the oral glucose tolerance, non-diabetic rats were treated with the leaf and flower extracts at the same doses, along with a reference drug, glibenclamide (10 mg/kg, p.o.). Glucose (2 g/kg, p.o.) was then administered to these animals, and their serum glucose levels were measured at intervals of 0, 1.5, 3, and 5-hours post-administration.

In a separate experiment, streptozotocin-induced diabetic rats were treated with the same doses of the leaf and flower extracts, while normal control rats were given either glibenclamide or 0.5 ml of 5% Tween-80 solution. The treatment lasted for 27 days, and blood samples were collected from all groups via retro-orbital puncture on days 7, 14, 21, and 27. The serum glucose levels were then estimated using a glucose assay kit to determine the effectiveness of the treatments.                        Results:

The Calotropis gigantea leaves and flowers extracts were effective in lowering serum glucose levels in normal rats. Improvement in oral glucose tolerance was also registered by treatment with Calotropis gigantean. The administration of leaf and flower extracts to streptozotocin-induced diabetic rats showed a significant reduction in serum glucose levels.                                                                                                                                                                    Conclusion:

Calotropis gigantea shows promising anti-diabetic potential, making it a candidate for further pharmacological and clinical investigations. However, standardized extraction methods and human trials are necessary to validate its efficacy and safety for therapeutic use.                                                                                                                                                Keywords:

 Calotropis gigantea, Crown Flower, Anti-diabetic, Hypoglycaemic Activity, Traditional Medicine.